Evidence supporting the use of: Ferric citrate
For the health condition: Anemia
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Ferric citrate is scientifically validated for use in the management of anemia, particularly in patients with chronic kidney disease (CKD). Ferric citrate is an iron-based phosphate binder that not only helps control serum phosphate levels in CKD patients but also provides bioavailable iron. Randomized controlled trials and meta-analyses have demonstrated that ferric citrate effectively increases serum ferritin and transferrin saturation, leading to improvements in hemoglobin levels in patients with CKD-associated anemia. This dual mechanism—phosphate binding and iron supplementation—has led to its approval by regulatory agencies such as the FDA for these indications.
Clinical studies, such as those published in journals like Nephrology Dialysis Transplantation and American Journal of Kidney Diseases, show that ferric citrate can reduce the need for intravenous iron and erythropoiesis-stimulating agents (ESAs) in dialysis patients. Its safety and efficacy profiles have been thoroughly evaluated in multiple phase III clinical trials. The evidence base supporting ferric citrate’s use for anemia is robust, and major nephrology guidelines acknowledge its role in CKD management. Thus, its use in supporting/treating anemia is grounded in strong scientific evidence rather than tradition.
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