Evidence supporting the use of: Folinic acid
For the health condition: Anemia
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Folinic acid (also known as leucovorin) is scientifically validated for use in certain types of anemia, specifically megaloblastic anemia resulting from folic acid deficiency. Folinic acid is a biologically active form of folate that can bypass some of the metabolic steps required to utilize folic acid. This property is especially important for patients with defects in folic acid absorption or metabolism. Clinical studies and medical guidelines confirm that folinic acid is effective in treating megaloblastic anemia caused by folate deficiency, which is characterized by the presence of abnormally large and immature red blood cells due to impaired DNA synthesis. This is distinct from iron-deficiency anemia, where folinic acid is not indicated.
Folinic acid is also used as an adjunct in cancer chemotherapy (notably with methotrexate), to "rescue" normal cells from the toxic effects of antifolate drugs, and in this context, it can help prevent or mitigate chemotherapy-induced anemia. The World Health Organization and various clinical guidelines endorse the use of folinic acid in these settings. Its use in other forms of anemia (such as anemia of chronic disease or iron-deficiency anemia) is not supported by scientific evidence.
In summary, folinic acid has a strong scientific basis for use in folate-deficiency megaloblastic anemia and in preventing anemia secondary to antifolate chemotherapy, with extensive clinical validation supporting its efficacy and safety in these contexts.
Other ingredients used for Anemia
5-methyltetrahydrofolate glucosamineAbalone
Abrus
Achyranthes
Adzuki bean
Aerva lanata
Agrimonia pilosa
Ajuga
Alchornea
Alfalfa
Algae
Algal protein
Allium tuberosum
amaranth
amino acids
anchovies
Angelica
animal protein
animal Tissue
apple
Ardisia
ashwagandha
aster root
Asteraceae
astragaloside
astragalus
Auricularia
Autumn Olive
Baccharoides anthelmintica
bael
banana
baobab
bean
bee pollen
bee products
beef
Beef liver
Beef Protein
beet
bermuda grass
berry
Bidens pilosa
biota seed
bird\'s nest
black cumin
black gram
black nightshade
blackberry
blackboard tree
Blepharis
Blue-Green Alage
Boerhavia diffusa
bok choy
Bombax
bone marrow
Borassus aethiopum
borassus palm
bovine
bovine liver
bovine protein
bovine spleen
breadnut
broad bean
broccoli
Brussel sprouts
Buckwheat
buffalo
Butea monosperma
butternut
C-phycocyanin
Caesalpinia crista
canihua
capillary artemisia
cashew
cassava
caterpillar mushroom
catjang cowpea
Celosia
cereal grass
chard
chestnut
chickpea protein
chlorella
Chlorophytum
cistanche
Citrus
coconut milk
Codonopsis
collard
cordyceps
cowpea
cumin
Curcuma
currant
Cyathula
Cynomorium
cytokines
date
deer root
dehydroascorbic acid
dodder
dog rose
Dolichos
dong quai
dong quai root
dragon fruit
dulse
dulse leaf
Eclipta
egg
Embelia
empresstree
Eupolyphaga sinensis
European five-finger grass
Fagopyrum
ferric ammonium citrate
ferric citrate
ferric orthophosphate
ferritin
fig
fish
fish protein
fo-ti
folate
folic acid
folinic acid
Foxtail millet
fructooligosaccharides (FOS)
fruit
fu ling
fulvic acid
ganoderma
garbanzo bean
garden cress
ginger
ginseng
Ginsenosides
goji berry
gooseberry
greens blend (proprietary)
Helicteres isora
herbal blend (proprietary)
hibiscus
hijiki
Histidine
horse gram
Huang hua
hyacinth bean
Hygrophila
Ilex
Indian coraltree
Indian tinospora
intrinsic factor
iron
jujube
jungli-bean
kale
kidney beans
kiwi
Kokilaksha
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
Labisia pumila
Lactoferrin
Land Cress
Laver
Legume protein
lemon
Lentil
Lentinula edodes mycelia
Leptadenia
licorice root
lingzhi
liquid liver fractions
little ironweed
longan
Loranthus
lotus seed
lucuma
Lycium
maca
Marine protein
Methylcobalamin
Microcos
Millet
millet seed
Mineral ascorbate
Molasses
Momordica
Morinda
Moringa
Morus
Mugwort
Mulberry
Mung bean
Nettle
Nigella seed
Nori
nut grass
oat
Onosma bracteatum
orange
oyster mushroom
Palmyra
parsley
paw paw
peony
Persimmon
Phaeophyceae
Phosphate ascorbate
Phycocyanin
Phyllanthus
Physalis angulata
Plankton
plantain
plum fruit
pollen
Polygonatum
pomegranate
pomelo
Portulaca
protein
Prunus
pumpkin
punarnava
purslane
pyridoxal-5-phosphate (P-5-P)
quail egg
quinoa
Rehmannia
rehmannia glutinosa
reishi mushroom
rhizome
riboflavin (vitamin B2)
root tuber
Rosa roxburghii
royal jelly
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
Rubus
Rumex acetosa
seaweed
sesame
Sesbania
shen-chu
shepherd's purse
shiitake mushroom
Shilajit
Sicklepod
Solanum anguivi
soybean
spinach
spirulina
Stellaria dichotoma
Stereospermum
suma
Tamarind
Taraxacum
Taxillus chinensis
Tayuya
Terminalia
Thaumatococcus daniellii
Tinospora cordifolia
trace minerals
Trichosanthes
Triphala
Tropical jewel hisbiscus
Vegetable Protein
vitamin A
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
Wakame
Watercress
wheat germ
wheat grass
Wulinshen
Yeast
Yellow Dock
Zinc
Zucchini