Evidence supporting the use of: Folinic Acid
For the health condition: Anemia
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Folinic acid (also known as leucovorin) is scientifically validated for use in certain types of anemia, specifically megaloblastic anemia resulting from folic acid deficiency. Folinic acid is a biologically active form of folate that can bypass some of the metabolic steps required to utilize folic acid. This property is especially important for patients with defects in folic acid absorption or metabolism. Clinical studies and medical guidelines confirm that folinic acid is effective in treating megaloblastic anemia caused by folate deficiency, which is characterized by the presence of abnormally large and immature red blood cells due to impaired DNA synthesis. This is distinct from iron-deficiency anemia, where folinic acid is not indicated.
Folinic acid is also used as an adjunct in cancer chemotherapy (notably with methotrexate), to "rescue" normal cells from the toxic effects of antifolate drugs, and in this context, it can help prevent or mitigate chemotherapy-induced anemia. The World Health Organization and various clinical guidelines endorse the use of folinic acid in these settings. Its use in other forms of anemia (such as anemia of chronic disease or iron-deficiency anemia) is not supported by scientific evidence.
In summary, folinic acid has a strong scientific basis for use in folate-deficiency megaloblastic anemia and in preventing anemia secondary to antifolate chemotherapy, with extensive clinical validation supporting its efficacy and safety in these contexts.
Other ingredients used for Anemia
alfalfaamino acids
anchovies
apple
ashwagandha
astragalus
beet
black cumin
sesame
blackberry
bovine
bovine liver
bovine spleen
broccoli
brussel sprouts
caterpillar mushroom
catjang cowpea
chlorella
coconut milk
collard
cordyceps
dog rose
dong quai root
fish protein
folate
fructooligosaccharides (FOS)
fu ling
ginger
ginseng
gooseberry
greens blend (proprietary)
hibiscus
Indian tinospora
iron
jujube
kale
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lactoferrin
lemon
lentinula edodes mycelia
licorice root
liquid liver fractions
maca
mackerel
moringa
nettle
oat
orange
oyster mushroom
parsley
plantain
plum fruit
pollen
pomegranate
pomelo
protein
pumpkin
pyridoxal-5-phosphate (P-5-P)
quail egg
quinoa
redcurrant
rehmannia glutinosa
reishi mushroom
rhizome
riboflavin (vitamin B2)
sardines
shiitake mushroom
soybean
spinach
spirulina
tomato
triphala
vitamin A
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
watercress
wheat grass
mulberry
yeast
zinc
suma
tangerine
shen-chu
mugwort
nut grass
punarnava
tinospora cordifolia
blackboard tree
caesalpinia crista
rubia cordifolia
bee pollen
peony
lingzhi
morus
root tuber
cistanche
dodder
ganoderma
hyacinth bean
lotus seed
morinda
trichosanthes
dulse leaf
royal jelly
trace minerals
purslane
fulvic acid
aster root
shepherd's purse
wheat germ
biota seed
goji berry
paw paw
amaranth
millet seed
herbal blend (proprietary)
algae
kidney beans
chickpea protein
17beta-[{1-Ketoethyl}-androsta-1, 4-diene-3-one,17a-ol]
17a-di methyl-bol
5-methyltetrahydrofolate glucosamine
Animal Tissue
Ardisia
Angelica
Achyranthes
Auricularia
Abrus
Alchornea
Autumn Olive
Ajuga
Aerva lanata
Astragaloside
Adzuki bean
Agrimonia pilosa
Asteracea
Algal protein
Abalone
Allium tuberosum
Animal protein
Bermuda Grass
Bidens pilosa
Breadnut
Blepharis
Beef Protein
Butea monosperma
Beef
Beef liver
Buffalo
Bok Choy
Bone Marrow
Bovine Protein
Bael
Bean
Butternut
berry
Black Gram
Baccharoides anthelmintica
Broad Bean
Bee products
Black Nightshade
Bombax
Borassus Palm
Borassus aethiopum
Blue-Green Alage
banana
Baobab
Buckwheat
Boerhavia diffusa
Bird's nest
Cumin
Cowpea
Codonopsis
Cynomorium
Capillary Artemisia
Cyathula
Cashew
Citrus
Cereal grass
Chlorophytum
Chard
Chicken
Curcuma
C-Phycocyanin
Canihua
Chestnut
Cytokines
Cassava
Celosia
Currant
Duodenum
Deer Root
Dehydroascorbic acid
Dragon Fruit
Dong Quai
Dolichos
Date
Dulse
Eupolyphaga sinensis
Empresstree
Egg
Eclipta
European-Five Finger Grass
Embelia
Fig
Folic Acid
Little ironweed
Molasses
Metal Salt
Zucchini