Evidence supporting the use of: Vitamin B6 (pyridoxal)
For the health condition: Anemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (specifically in its active form, pyridoxal 5'-phosphate) plays a critical role in heme biosynthesis, which is essential for the production of hemoglobin in red blood cells. Deficiency of vitamin B6 can lead to a specific type of anemia known as sideroblastic anemia, in which the body has adequate iron but cannot incorporate it properly into hemoglobin, leading to dysfunctional red blood cells and reduced oxygen-carrying capacity. Clinical evidence supports the use of vitamin B6 supplementation in cases of vitamin B6–responsive sideroblastic anemia, which is a rare but well-documented condition. In these cases, administration of vitamin B6 can correct the anemia and normalize red blood cell production.

However, the use of vitamin B6 for more common forms of anemia (such as iron-deficiency anemia or anemia of chronic disease) is not supported by strong scientific evidence, as these conditions have different underlying causes. In the general population, vitamin B6 supplementation is not considered an effective or necessary treatment for most types of anemia unless a deficiency is present. The primary scientific support is thus limited to specific subtypes of anemia directly linked to vitamin B6 deficiency. This is reflected in clinical guidelines and reviews, which recommend targeted rather than routine use.

In summary, there is scientific validation for the use of vitamin B6 in certain rare forms of anemia, especially sideroblastic anemia associated with deficiency, but evidence does not support its routine use for anemia in general.

More about Vitamin B6 (pyridoxal)
More about Anemia

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Products containing Vitamin B6 (pyridoxal)

We currently have no products on Vitabase that contain this ingredient.