Evidence supporting the use of: Vitamin E (alpha-tocopherol succinate)
For the health condition: Anemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (alpha-tocopherol succinate) has some scientific evidence supporting its role in the management of certain types of anemia, particularly hemolytic anemia associated with vitamin E deficiency and some inherited anemias such as thalassemia and sickle cell anemia. Vitamin E is a potent antioxidant, and its main proposed mechanism is the protection of red blood cell membranes from oxidative damage. In hemolytic anemia, red blood cells are destroyed prematurely, often due to increased oxidative stress. Several studies, especially in pediatric populations with chronic hemolytic anemias (e.g., thalassemia major), have shown that vitamin E supplementation can reduce markers of oxidative damage and, in some cases, modestly improve anemia parameters. However, evidence for its benefit in iron deficiency anemia or anemia of chronic disease is lacking.

Randomized controlled trials are limited, and results are mixed. The evidence base is primarily composed of small clinical trials and observational studies, with few large-scale, definitive trials. There is no strong evidence that vitamin E alone can treat most types of anemia, but in specific patient groups with increased oxidative hemolysis, supplementation may be considered as adjunctive therapy. The use of alpha-tocopherol succinate is based on its better stability and bioavailability compared to other forms. Overall, while there is a scientific rationale and limited supporting evidence, vitamin E is not a primary treatment for anemia and should only be used in select cases under medical supervision.

More about Vitamin E (alpha-tocopherol succinate)
More about Anemia

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Products containing Vitamin E (alpha-tocopherol succinate)

We currently have no products on Vitabase that contain this ingredient.