Evidence supporting the use of: Arginine orotate
For the health condition: Angina

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Arginine orotate has been traditionally used in some countries as a supportive treatment for angina pectoris, especially in the 1970s and 1980s. The rationale behind its use is twofold: L-arginine is a precursor to nitric oxide (NO), a molecule that helps dilate blood vessels and potentially improve blood flow to the heart muscle, while orotate was once believed to have beneficial effects on heart metabolism. Early clinical studies, mainly from Europe, suggested some benefit in reducing anginal attacks and improving exercise tolerance, but these studies were generally small, not rigorously controlled, and are now considered outdated by modern standards. No large, high-quality randomized controlled trials have confirmed its efficacy, and arginine orotate is rarely mentioned in current angina management guidelines. More recent research on L-arginine alone (not as the orotate salt) has produced mixed results, and the specific contribution of orotate remains unproven. As a result, while there is some historical precedent for its use in angina, scientific evidence is weak and insufficient to recommend it over established therapies.

More about Arginine orotate
More about Angina

Other health conditions supported by Arginine orotate

Angina
Congestive Heart Failure
Fatigue
Heart (weakness)

Products containing Arginine orotate

We currently have no products on Vitabase that contain this ingredient.