Barleria, particularly Barleria prionitis, is a plant used in traditional medicine systems such as Ayurveda and Unani. Its use for cardiovascular conditions, including angina, is primarily based on traditional knowledge rather than robust scientific evidence. In traditional Ayurvedic practice, parts of the Barleria plant are sometimes used to "improve blood circulation" or "strengthen the heart," but these indications are generally broad and not specific to angina pectoris (chest pain due to reduced blood flow to the heart). There are folkloric reports of Barleria preparations being used for heart-related ailments; however, the documentation of these uses is limited, and angina is rarely specified as the target condition.

Scientific studies on Barleria species have mostly focused on their anti-inflammatory, antioxidant, and antimicrobial properties. A few preclinical studies suggest potential cardioprotective effects in animal models, such as reduction of oxidative stress or improvement of cardiac markers, but these studies are preliminary, not specific to angina, and have not progressed to human trials. No high-quality clinical trials or systematic reviews support the use of Barleria for the treatment or management of angina in humans.

In summary, use of Barleria for angina is justified by tradition with very weak evidence, and there is a lack of rigorous scientific validation.