Evidence supporting the use of: Citrulline
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline is a non-essential amino acid involved in the urea cycle and nitric oxide (NO) production. Its use for angina (chest pain due to reduced blood flow to the heart) is based on its ability to increase L-arginine and NO levels, which promote vasodilation and may improve blood flow. Several small clinical studies have explored the effect of citrulline supplementation in cardiovascular conditions. Some trials have shown that citrulline can improve endothelial function and reduce blood pressure, and a few small studies have observed improvements in exercise tolerance and reduced angina symptoms in patients with stable angina. However, these studies are generally limited by small sample sizes, short durations, and methodological shortcomings. There is not yet robust, large-scale clinical evidence to firmly establish its efficacy for angina treatment. Current guidelines do not recommend citrulline as a standard therapy for angina. In summary, while there is some scientific rationale and preliminary research suggesting possible benefits of citrulline for improving symptoms of angina, the overall level of evidence is weak (rated 2 out of 5), and more high-quality clinical trials are needed to confirm its efficacy and safety for this indication.

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Products containing Citrulline

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