Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is used to support the treatment of angina primarily based on scientific rationale and limited clinical evidence. CoQ10 is a naturally occurring antioxidant involved in mitochondrial energy production, particularly in heart muscle cells. The rationale for its use in angina hinges on the idea that improving cellular energy production and reducing oxidative stress may help the heart function more efficiently, especially under the stress of limited oxygen supply, as occurs in angina.

Several small clinical studies and randomized controlled trials have investigated CoQ10 in patients with stable angina. Some of these studies have shown that CoQ10 supplementation can reduce the frequency and severity of angina attacks, improve exercise tolerance, and decrease the need for nitroglycerin. For example, a double-blind, placebo-controlled study in the 1990s found that patients taking 150 mg/day of CoQ10 had fewer angina episodes and improved electrocardiogram (ECG) parameters during exercise testing.

However, the overall quality of evidence is moderate to low due to small sample sizes, short durations, and methodological limitations. Major cardiology guidelines do not currently recommend CoQ10 as a standard therapy for angina, and more robust, larger-scale studies are needed. In summary, while there is scientific plausibility and some supportive clinical data, the evidence is not strong or conclusive, justifying a modest evidence rating.

More about coenzyme Q10 (CoQ10)
More about Angina

Other ingredients used for Angina

Other health conditions supported by coenzyme Q10 (CoQ10)

Products containing coenzyme Q10 (CoQ10)

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Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
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