Evidence supporting the use of: Flavonoid glycosides
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoid glycosides—plant-derived compounds consisting of a flavonoid linked to a sugar moiety—have been studied for their cardiovascular effects, including potential benefits in angina pectoris. The scientific rationale is based on their antioxidant, anti-inflammatory, and vasodilatory properties. Several clinical and preclinical studies suggest that flavonoid glycosides can improve endothelial function, reduce oxidative stress, and enhance coronary blood flow, which may theoretically benefit patients with angina by improving myocardial oxygen supply and reducing ischemic injury.

Some specific flavonoid glycosides, such as those found in Crataegus (hawthorn) extracts, have been the subject of randomized, placebo-controlled trials in patients with chronic stable angina. These trials have reported modest improvements in exercise tolerance and symptoms. However, the overall quality and number of these studies are limited, and systematic reviews generally conclude that while there is some evidence for benefit, it is not robust or conclusive. The European Medicines Agency recognizes hawthorn extract for use in mild heart failure, but not specifically for angina.

In summary, while there is some scientific evidence suggesting potential benefit of flavonoid glycosides in angina—mainly from small trials and mechanistic studies—the evidence is limited and not sufficient to recommend routine use. Large, well-designed clinical trials are needed to establish efficacy and safety more clearly.

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