Evidence supporting the use of: Flavonoids
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids are a diverse group of polyphenolic compounds found in many fruits, vegetables, and plant-derived foods. Their use for angina is primarily supported by scientific, rather than traditional, evidence. Flavonoids have been shown in numerous preclinical and clinical studies to exert beneficial effects on cardiovascular health, mainly through antioxidant, anti-inflammatory, endothelial function-enhancing, and vasodilatory properties. Several epidemiological studies have linked a high dietary intake of flavonoids with reduced risk of coronary artery disease, which is the underlying cause of angina.

Specifically, flavonoids such as quercetin, rutin, and those found in cocoa and tea have demonstrated the capacity to improve endothelial function, reduce platelet aggregation, and decrease oxidative stress, all of which are relevant to the pathophysiology of angina. Some small clinical trials suggest that flavonoid supplementation can improve exercise tolerance and reduce symptoms in patients with stable angina, though the data are not as robust or consistent as for standard pharmaceutical therapies.

Overall, while there is moderate scientific evidence supporting the adjunctive use of flavonoids for cardiovascular protection and potential angina symptom relief, they are not considered primary therapy. More large-scale, well-designed clinical trials are needed to fully establish their efficacy for angina specifically.

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