Evidence supporting the use of: Ligustrazin
For the health condition: Angina

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustrazin (tetramethylpyrazine) is a bioactive compound extracted from the traditional Chinese medicinal herb Ligusticum chuanxiong. It has a long history of use in traditional Chinese medicine (TCM), particularly for the treatment of cardiovascular and cerebrovascular diseases, including angina pectoris. The justification for its use in angina is therefore primarily traditional, with its application based on the TCM concepts of promoting blood circulation and removing blood stasis.

Some preclinical and limited clinical studies suggest that ligustrazin may have vasodilatory effects, inhibit platelet aggregation, and improve microcirculation, which are theoretically beneficial in angina. However, the quality of clinical evidence is generally low, with most studies being small, poorly controlled, or lacking rigorous methodology. Systematic reviews of Chinese literature indicate that ligustrazin injections may improve symptoms of angina when used as an adjunct to conventional therapies, but the evidence is not robust enough to support widespread clinical adoption outside of traditional practice or without further high-quality randomized controlled trials.

In summary, the use of ligustrazin for angina is supported by a strong tradition in TCM and some preliminary scientific exploration, but high-quality scientific validation is still lacking. Therefore, the rating for evidence is moderate, reflecting the need for more rigorous research.

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