Evidence supporting the use of: Lovastatin
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lovastatin is a statin medication primarily used to lower cholesterol levels by inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis. Its use in supporting or treating angina pectoris is not direct, as Lovastatin does not provide acute relief of angina symptoms. However, there is scientific validation for its role in the long-term management of patients with angina, especially those with underlying coronary artery disease (CAD).

Clinical studies, such as the Scandinavian Simvastatin Survival Study (4S) and others, have demonstrated that statins reduce cardiovascular events by stabilizing atherosclerotic plaques, reducing inflammation, and improving endothelial function. These effects can indirectly benefit patients with angina by decreasing the progression of coronary atherosclerosis, thus reducing the frequency and severity of anginal episodes over time and lowering the risk of myocardial infarction and death.

Lovastatin and other statins are recommended by major guidelines (e.g., ACC/AHA) as part of the standard therapy for patients with chronic stable angina, primarily to manage dyslipidemia and reduce long-term cardiovascular risk. However, they are adjuncts to, not replacements for, anti-anginal therapies such as nitrates, beta-blockers, or calcium channel blockers. The evidence supporting their use for angina stems from large, well-conducted clinical trials focused on cardiovascular outcomes in patients at risk for, or diagnosed with, coronary artery disease.

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Products containing Lovastatin

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