Evidence supporting the use of: Nitrate (unspecified)
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Nitrates are one of the cornerstone treatments for angina pectoris, a clinical syndrome characterized by chest pain due to myocardial ischemia. The use of nitrates, such as nitroglycerin, is strongly supported by scientific evidence and is included in international guidelines for the management of angina. Nitrates act as vasodilators, primarily by releasing nitric oxide, which relaxes vascular smooth muscle. This leads to venodilation, reduced preload, and decreased myocardial oxygen demand. Additionally, nitrates dilate coronary arteries, improving oxygen supply to the heart muscle.

The efficacy of nitrates in treating angina has been established through numerous clinical trials and decades of clinical practice. Sublingual nitroglycerin provides rapid relief from acute angina attacks, while long-acting nitrates are used for prophylaxis. Major cardiology guidelines, including those from the American Heart Association and European Society of Cardiology, recommend nitrates for both acute relief and prevention of angina symptoms. Clinical evidence supports their ability to alleviate symptoms, improve exercise tolerance, and reduce the frequency of angina episodes, though there is no evidence they reduce mortality in stable angina.

In summary, the use of nitrates for angina is grounded in extensive scientific research and is a well-established, evidence-based therapy for symptomatic management of this condition.

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