Evidence supporting the use of: Nitric Oxide
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Nitric Oxide (NO) is scientifically validated for use in the treatment of angina, primarily through its role in the mechanism of action of drugs such as nitroglycerin and other organic nitrates. These medications act as prodrugs that are converted in the body to nitric oxide. NO is a potent endogenous vasodilator that works by stimulating guanylate cyclase in vascular smooth muscle, leading to increased cyclic GMP and, consequently, smooth muscle relaxation. The resulting vasodilation reduces preload and afterload, thereby decreasing myocardial oxygen demand and alleviating the symptoms of angina pectoris.

The use of nitroglycerin in angina dates back to the late 19th century, and its clinical benefit is well established through numerous clinical trials and decades of widespread use. The scientific rationale for its efficacy is strongly supported by our understanding of NO’s role in vascular tone regulation. Sublingual nitroglycerin remains a first-line therapy for acute angina attacks, while longer-acting nitrates are used in chronic management. There is also evidence that impaired NO bioavailability contributes to endothelial dysfunction in coronary artery disease, further supporting the therapeutic targeting of NO pathways in these patients.

Overall, the use of NO donors in angina is supported by a robust body of clinical and mechanistic evidence, earning it the highest rating on the evidence scale.

More about Nitric Oxide
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