Evidence supporting the use of: Omega-3
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been studied for their cardiovascular benefits, including their potential role in the management of angina pectoris. Several mechanisms have been proposed for their beneficial effects, such as anti-inflammatory properties, reduction of triglyceride levels, improvement in endothelial function, and antithrombotic effects. These mechanisms could, in theory, reduce the frequency or severity of angina attacks by improving overall heart health and blood flow to the myocardium.

However, direct evidence specifically supporting the use of omega-3 supplements to treat or prevent angina symptoms is limited. Most clinical trials and meta-analyses focus on broader cardiovascular outcomes such as myocardial infarction, stroke, and cardiac death rather than angina frequency or severity itself. Some early studies suggested a modest benefit, but more recent large-scale randomized controlled trials (e.g., the ASCEND, VITAL, and REDUCE-IT trials) have shown mixed results, and none have conclusively demonstrated a reduction in angina symptoms.

Guidelines from major cardiovascular organizations do not currently recommend omega-3 fatty acids specifically for angina management, though they may be advised as part of a heart-healthy diet. In summary, while there is a scientific rationale and some indirect supporting evidence for omega-3s in cardiovascular health, robust evidence directly supporting their use in angina is lacking.

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Products containing Omega-3

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