Evidence supporting the use of: Polyphenols (unspecified)
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a diverse group of naturally occurring compounds found in plants, particularly abundant in fruits, vegetables, tea, red wine, and cocoa. There is some scientific evidence suggesting potential cardiovascular benefits of polyphenols, particularly due to their antioxidant, anti-inflammatory, and endothelial function-improving properties. Regarding angina, which is chest pain typically caused by reduced blood flow to the heart (often due to coronary artery disease), several studies have explored whether polyphenol-rich foods or extracts may improve symptoms or underlying mechanisms. A few small clinical trials and observational studies suggest that certain polyphenols (notably those in cocoa, green tea, and red wine) can improve endothelial function, reduce blood pressure, and decrease markers of oxidative stress, all of which are relevant to angina. However, direct evidence specifically targeting angina symptoms is limited. Most studies focus on surrogate markers (like flow-mediated dilation or nitric oxide availability) rather than clinical endpoints such as angina frequency or exercise tolerance. A 2017 review in Nutrients noted that while polyphenols show promise in improving vascular function and reducing cardiovascular risk factors, high-quality randomized controlled trials (RCTs) specifically assessing their effect on angina are lacking. Thus, while there is a scientific rationale and some supporting evidence regarding polyphenols and cardiovascular health, their direct role in treating or supporting angina remains only modestly supported by current scientific data.

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