Evidence supporting the use of: Puerarin
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin and Its Use in Angina: Scientific Evidence

Puerarin is an isoflavone derived from the root of Pueraria lobata (Kudzu), widely used in Traditional Chinese Medicine. Its application for angina pectoris (chest pain due to coronary heart disease) has been investigated in both traditional and modern clinical contexts.

Several clinical studies, mostly from China, have explored the effects of puerarin (often administered intravenously) as an adjunct to standard angina treatments. Meta-analyses and systematic reviews of these randomized controlled trials suggest that puerarin may improve symptoms of angina, reduce the frequency of anginal attacks, and enhance electrocardiogram (ECG) outcomes. Proposed mechanisms include vasodilation, improvement of coronary blood flow, reduction of oxidative stress, and inhibition of platelet aggregation. Animal studies also show that puerarin can protect cardiac tissue from ischemic injury.

However, the quality of available clinical evidence is moderate to low. Many studies suffer from small sample sizes, inadequate blinding, potential publication bias, and lack of long-term follow-up. While results are promising, most reviews caution that larger, high-quality trials are needed to confirm efficacy and safety.

In summary, there is some scientific evidence—though not robust by Western standards—that puerarin may benefit angina patients, especially as an adjunct to conventional therapies. Its use is better supported by clinical research than solely by tradition, but the evidence base is not strong enough for widespread endorsement outside of certain clinical settings.

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Products containing Puerarin

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