Evidence supporting the use of: Taurine
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Taurine, a sulfur-containing amino acid, has been investigated for its potential cardiovascular benefits, including its use in angina. Several preclinical and small clinical studies suggest that taurine may exert protective effects on the heart by improving endothelial function, reducing oxidative stress, modulating calcium homeostasis, and potentially enhancing myocardial energy metabolism. These mechanisms are relevant to ischemic heart conditions like angina, where impaired blood flow and oxygen delivery to the heart muscle cause chest pain.

A few small clinical trials and observational studies have examined taurine supplementation in patients with heart disease, including angina. Some findings indicate modest improvements in exercise tolerance, reduction of angina attacks, and better electrocardiographic parameters, likely due to taurine’s effects on myocardial contractility and anti-ischemic properties. For example, a small double-blind, placebo-controlled study (Zhang M et al., 2004) showed that taurine supplementation improved exercise capacity in patients with stable angina. However, these studies are generally limited by small sample sizes, short durations, and methodological weaknesses.

There is no robust, large-scale clinical evidence or established clinical guideline recommending taurine for angina. Most evidence comes from animal studies, in vitro experiments, or small pilot trials. Thus, while the rationale for taurine use in angina is grounded in plausible biological mechanisms and early clinical data, the overall strength of scientific evidence is low to moderate.

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