Evidence supporting the use of: Ubiquinol
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ubiquinol, the reduced and active antioxidant form of Coenzyme Q10 (CoQ10), is sometimes used as an adjunct treatment for angina (chest pain caused by reduced blood flow to the heart). The scientific rationale is based on CoQ10's role in mitochondrial bioenergetics and its antioxidant properties, which may improve cardiac muscle energy production and reduce oxidative stress. Several small randomized controlled trials and meta-analyses have suggested that CoQ10 supplementation (often as ubiquinone, but ubiquinol is considered more bioavailable) can reduce the frequency and severity of angina episodes and improve exercise tolerance in patients with chronic stable angina. For example, a 2014 meta-analysis in Atherosclerosis reported modest improvements in exercise capacity and reduction in angina symptoms with CoQ10 supplementation. However, study quality varies, sample sizes are generally small, and most studies use CoQ10 (ubiquinone), with far fewer directly investigating ubiquinol. Current guidelines do not recommend ubiquinol as standard therapy for angina, but it may be considered as adjunctive support. Overall, while there is some scientific evidence for its potential benefit, it is not robust, and more large-scale, high-quality studies are needed to firmly establish efficacy.

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