Evidence supporting the use of: Unsaturated fatty acid
For the health condition: Angina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Unsaturated fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs) such as those found in fish oil (eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA), have been studied for their cardiovascular benefits, including potential roles in the management of angina pectoris. The scientific rationale is based on their ability to reduce triglyceride levels, decrease platelet aggregation, improve endothelial function, reduce inflammation, and potentially stabilize atherosclerotic plaques. These mechanisms may theoretically reduce the frequency or severity of angina by improving coronary blood flow and reducing the risk of cardiac events.

However, while observational studies and some early clinical trials suggested cardiovascular benefits of omega-3 fatty acids, more recent large-scale randomized controlled trials (e.g., ASCEND, VITAL, and OMEMI) have shown mixed or modest results for major cardiovascular outcomes, with limited direct evidence for angina symptom relief specifically. Guidelines from organizations such as the American Heart Association acknowledge the general cardiovascular benefits of unsaturated fatty acids but do not specifically recommend them for angina treatment. Their use is more robustly supported for general cardiovascular risk reduction rather than for direct angina management.

In summary, there is some scientific basis for the use of unsaturated fatty acids to support cardiovascular health, but the direct evidence for their efficacy in treating or managing angina is limited and rated as low to moderate (2/5). They may be used as adjuncts to conventional therapy rather than as primary treatments for angina.

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Products containing Unsaturated fatty acid

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