Synopsis

Source of validity: Scientific
Rating (out of 5): 2

2′-Fucosyllactose (2′-FL) is a human milk oligosaccharide (HMO) naturally present in significant amounts in human breast milk. Its use as an adjunct or alternative to antibiotics is not rooted in traditional medicine, but rather in emerging scientific research. The primary rationale for 2′-FL’s use in this context is its ability to modulate the gut microbiota and inhibit the adhesion of certain pathogenic bacteria to intestinal cells, thereby reducing the risk of infections. Preclinical and some clinical studies demonstrate that 2′-FL can promote the growth of beneficial bacteria such as Bifidobacterium species, which can outcompete pathogens and may contribute to a healthier intestinal environment. Additionally, 2′-FL can function as a decoy receptor, binding to pathogens like Escherichia coli and Campylobacter, thus preventing their attachment to the gut lining and subsequent infection. There is also evidence suggesting that 2′-FL may modulate immune responses. However, while these properties are promising, direct evidence supporting the use of 2′-FL as a true alternative to antibiotics in the treatment or prevention of bacterial infections in humans remains limited. Most studies so far are preclinical, and clinical trials are in early stages or focus on infant populations. As such, the evidence base is not yet strong enough to recommend 2′-FL as a replacement for antibiotics, but it may offer supportive or adjunctive benefits, particularly in the context of infant health and potentially in reducing the need for antibiotics in some scenarios.

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Products containing 2'-Fucosyllactose

Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
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Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla