Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Aloe macroclada, a species native to Madagascar, is traditionally used in Malagasy folk medicine for a variety of ailments, including as an alternative to antibiotics for infections. The ethnobotanical literature documents its use in treating wounds, skin infections, and sometimes internal infections, relying on preparations such as sap or decoctions. The rationale is similar to other Aloe species: the presence of bioactive compounds such as anthraquinones and phenolics, which are believed to have antimicrobial properties. However, while some laboratory studies on related Aloe species (e.g., Aloe vera, Aloe arborescens) show modest antibacterial effects, there is very limited direct scientific research specifically examining the antimicrobial efficacy of Aloe macroclada. Most of the evidence supporting its use as an antibiotic alternative comes from traditional knowledge and anecdotal reports rather than controlled clinical or in vitro studies. Therefore, while its use as an antibiotic alternative is well-established in local traditional practice, scientific validation for its efficacy and safety in this context remains minimal. Further research is needed to determine its actual antimicrobial spectrum, active constituents, and potential application in modern phytotherapy.

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