Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aucubin is an iridoid glycoside found in various medicinal plants such as Plantago species. Its use as an alternative or supportive agent to antibiotics is primarily justified by scientific evidence, although this evidence is limited and largely based on in vitro and animal studies rather than robust clinical trials in humans. Several studies have demonstrated that aucubin possesses antimicrobial activity against a variety of bacterial strains, including some that are pathogenic to humans. For example, research has shown that aucubin can inhibit the growth of Staphylococcus aureus and Escherichia coli in laboratory settings. Additionally, aucubin has been reported to exert anti-inflammatory and immunomodulatory effects, which may contribute indirectly to infection control. However, there is a lack of high-quality clinical trials confirming its efficacy as a standalone treatment for bacterial infections in humans or as a direct replacement for conventional antibiotics. The evidence available suggests potential but is not sufficient to recommend aucubin as a primary alternative to antibiotics in clinical practice. Thus, the scientific rating is 2/5, reflecting preliminary but non-conclusive support.

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