Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacillus subtilis natto has garnered scientific interest as a potential alternative or adjunct to antibiotics, mainly due to its probiotic properties and ability to modulate the gut microbiome. Several in vitro and animal studies have demonstrated that strains of Bacillus subtilis can inhibit the growth of various pathogenic bacteria by producing antimicrobial compounds such as subtilin and other bacteriocins. These antimicrobial peptides can suppress the proliferation of certain pathogens, including Staphylococcus aureus and Escherichia coli, in laboratory settings.

There is also evidence suggesting that Bacillus subtilis natto may enhance the immune response, which could theoretically contribute to its protective effects against infections. Some small clinical studies in humans have shown that supplementation with Bacillus subtilis can reduce the incidence or severity of gastrointestinal infections, particularly in agricultural settings (e.g., livestock). However, robust clinical trials in humans as direct alternatives to antibiotics for infectious diseases are lacking.

Overall, while there is scientific rationale and some preliminary evidence for the antimicrobial and immune-modulating effects of Bacillus subtilis natto, the current evidence is limited (rated 2/5) and does not yet support its use as a standalone alternative to antibiotics in human medicine. More rigorous clinical research is needed to establish efficacy and safety for this purpose.

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