Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Brevibacillus laterosporus is a spore-forming bacterium that has been investigated as a probiotic and as a potential alternative to antibiotics, especially in agriculture and animal husbandry. Its use as an antibiotic alternative is supported by some scientific studies, but the evidence is still limited and mostly preclinical. Research indicates that B. laterosporus can produce antimicrobial compounds such as bacteriocins, which can inhibit the growth of pathogenic bacteria, including Salmonella, Escherichia coli, and Staphylococcus aureus. Several in vitro and animal studies have reported benefits in reducing pathogen loads and improving gut health in livestock, such as poultry and aquaculture species, when supplemented with B. laterosporus. However, robust clinical trials in humans are lacking, and its use as a direct antibiotic alternative in human medicine is not yet established.

In summary, while there is some scientific basis for the use of B. laterosporus as an alternative to antibiotics—primarily through production of antimicrobial substances and competitive exclusion of pathogens—the current evidence is moderate and primarily derived from non-human studies. More rigorous research, including well-designed human clinical trials, is needed to validate its efficacy and safety for this purpose. Therefore, the evidence rating for this use is 2 out of 5.

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