Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cinnamic acid has been studied for its antimicrobial properties, which underpins some interest in its use as an adjunct or alternative to antibiotics. Several in vitro studies have demonstrated that cinnamic acid and its derivatives exhibit inhibitory effects against a variety of bacterial and fungal pathogens, including Staphylococcus aureus, Escherichia coli, and Candida albicans. The proposed mechanisms include disruption of microbial cell membranes and inhibition of biofilm formation. However, most of this evidence is limited to laboratory (in vitro) models, and there is a lack of robust clinical trials in humans supporting its efficacy as an antibiotic alternative or adjunct.

While cinnamic acid is a natural constituent of cinnamon and other plants traditionally used for infections, its isolated use for antimicrobial purposes is not a major feature of traditional medicine systems. The scientific interest is more recent, and although the compound shows promise as a potential antimicrobial agent, the evidence remains preliminary. No established clinical guidelines endorse cinnamic acid as an antibiotic alternative or adjunct. Overall, its use in this context is justified by emerging scientific evidence, but the current level of evidence is modest and does not yet support routine use in clinical practice.

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