Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Drug delivery systems are scientifically validated as critical tools in supporting and enhancing the efficacy of antibiotics and their alternatives. The main goal of advanced delivery systems—such as liposomes, nanoparticles, hydrogels, and micelles—is to optimize the pharmacokinetics and pharmacodynamics of antimicrobial agents, especially in the face of rising antibiotic resistance. Scientific studies demonstrate that these systems can improve drug solubility, stability, and bioavailability, while also enabling targeted delivery to infection sites and minimizing systemic side effects. For example, liposomal encapsulation of antibiotics like vancomycin can increase drug concentration at infection sites and reduce toxicity. Additionally, delivery systems are being explored to support the use of non-antibiotic alternatives, such as antimicrobial peptides, bacteriophages, or plant-derived compounds, by protecting these labile molecules from degradation and enhancing their penetration into tissues or biofilms. Numerous in vitro and in vivo studies, as well as early clinical investigations, support the utility of these technologies in both augmenting traditional antibiotics and facilitating the use of novel alternatives. However, while preclinical evidence is robust, large-scale clinical validation is ongoing, which is why the evidence level is rated at 4 out of 5.

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