Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fructo-oligosaccharides (FOS) are short-chain carbohydrates classified as prebiotics, meaning they selectively stimulate the growth and activity of beneficial gut bacteria such as Bifidobacteria and Lactobacilli. Their use as an alternative or adjunct to antibiotics is based on the premise that a healthy, balanced microbiota can suppress the growth of pathogenic organisms and help maintain intestinal health, especially after or during antibiotic therapy.

There is emerging scientific evidence supporting the role of FOS in promoting gut health and potentially reducing the risk of infections by inhibiting pathogen adhesion and enhancing the gut barrier. However, FOS itself does not possess direct antibacterial activity and is not considered a replacement for antibiotics in treating active bacterial infections.

Some clinical studies have shown that FOS supplementation can help restore gut microbiota after antibiotic treatment and may reduce the duration or severity of certain infections, particularly in the gastrointestinal tract. However, the evidence is still limited, with most studies being small, of short duration, or focused on prevention rather than treatment. Systematic reviews and meta-analyses conclude that while FOS can support gut health and reduce antibiotic-associated side effects like diarrhea, there is insufficient evidence to recommend FOS as an alternative to antibiotics for treating infections.

In summary, FOS is scientifically validated as a supportive agent for gut microbiota, especially during or after antibiotic use, but not as a direct alternative to antibiotics for infection treatment. The evidence level is moderate but not robust (rated 2/5).

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