Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycerol monolaurate (GML), also known as monolaurin, has garnered scientific interest as a potential alternative or adjunct to antibiotics, primarily due to its broad-spectrum antimicrobial properties. GML is a naturally occurring monoglyceride found in coconut oil and breast milk. Several in vitro and animal studies have demonstrated that GML can inhibit the growth of various Gram-positive bacteria, including Staphylococcus aureus (including MRSA), Streptococcus species, and Clostridium species. Its mechanism of action involves disrupting bacterial cell membranes and interfering with signal transduction pathways, which can prevent biofilm formation and toxin production. Some studies have shown that GML is effective against certain viruses and fungi as well. Despite these promising laboratory findings, clinical evidence in humans remains limited. A few small-scale studies and preclinical trials have suggested that GML can reduce bacterial colonization and infection rates, but robust, large-scale clinical trials are lacking. Regulatory agencies have not approved GML as a standalone antibiotic alternative, though it is generally recognized as safe (GRAS) for use in foods. Thus, while there is a reasonable scientific basis for considering GML as a supportive agent or alternative in the context of antibiotic resistance, its efficacy and safety in humans require further validation.

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