Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Hedyotis (often referring to species such as Hedyotis diffusa, also known as Oldenlandia) is used primarily in traditional medicine systems, especially in Traditional Chinese Medicine (TCM), as a remedy for infections and conditions that might otherwise be treated with antibiotics in modern medicine. The use of Hedyotis as an "antibiotic alternative" is based on its inclusion in classical herbal formulas intended to "clear heat and detoxify," which are TCM concepts often associated with infectious or inflammatory diseases. There are some in vitro studies indicating that extracts of Hedyotis diffusa may have antibacterial activity against certain pathogens, but these findings are preliminary and not robustly validated in human clinical trials. No major pharmacological or clinical studies have established Hedyotis as a reliable alternative to antibiotics in modern medicine. The evidence, therefore, is largely traditional with limited supporting laboratory data and minimal clinical validation, justifying a low evidence rating. Use outside of traditional practice should be approached with caution, as efficacy and safety profiles are not established to the standards of conventional antibiotics.

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