Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydroxycinnamic acids, a group of phenolic compounds found in many plants (such as caffeic acid, ferulic acid, and p-coumaric acid), have been investigated for their antimicrobial properties, which provide some scientific basis for their consideration as adjuncts or alternatives to antibiotics. In vitro studies have shown that hydroxycinnamic acids can inhibit the growth of various pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Proposed mechanisms include disruption of bacterial cell membranes, interference with microbial enzyme systems, and antioxidant activities that may reduce bacterial virulence. However, most of this evidence is preclinical, relying on cell culture or animal models, and there is a lack of robust clinical trials demonstrating efficacy in humans as a standalone or supportive treatment to antibiotics.

Some research also suggests a synergistic effect when hydroxycinnamic acids are used in combination with certain antibiotics, potentially helping to overcome bacterial resistance or reduce required antibiotic dosages. Despite these promising findings, the overall quality and quantity of evidence remains limited, and hydroxycinnamic acids are not currently recommended as replacements for antibiotics in clinical practice.

In summary, while there is some scientific evidence supporting antimicrobial effects of hydroxycinnamic acids, its use as an antibiotic alternative is not well validated in humans, and more research is needed to establish clinical relevance.

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