Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactoperoxidase is an enzyme found in milk, saliva, and other secretions, and it plays a role in the innate immune system by catalyzing the oxidation of thiocyanate ions in the presence of hydrogen peroxide, producing antimicrobial compounds (primarily hypothiocyanite). Its use as a potential alternative or adjunct to antibiotics is supported by a moderate body of scientific evidence, particularly in applications such as oral care, dairy preservation, and wound care. Several in vitro and in vivo studies have demonstrated that the lactoperoxidase system can inhibit the growth of a broad spectrum of bacteria, including some antibiotic-resistant strains, as well as certain fungi and viruses. In the food industry, lactoperoxidase is used to preserve raw milk and extend its shelf life by reducing microbial contamination. In dentistry, lactoperoxidase-containing oral care products have shown efficacy in reducing dental plaque and gingivitis. However, while these antimicrobial effects are well-documented, clinical evidence supporting lactoperoxidase as a direct replacement for antibiotics in systemic infections is limited. Most research focuses on topical or localized use and on prevention rather than treatment of established infections. The enzyme is generally considered safe and non-toxic at the concentrations used in commercial products. In summary, lactoperoxidase shows promise as a supportive or alternative antimicrobial agent in specific applications, but more robust clinical trials are needed to fully establish its efficacy as a systemic antibiotic alternative.

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Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder