Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mannanoligosaccharides (MOS) are complex carbohydrates derived from the cell walls of yeast, particularly Saccharomyces cerevisiae. They are widely studied as alternatives to antibiotics in animal nutrition, especially in the poultry and swine industries. The interest in MOS stems from their ability to modulate gut microbiota, enhance immune function, and reduce pathogen colonization in the gastrointestinal tract. Scientific studies demonstrate that MOS can bind to pathogenic bacteria such as Salmonella and Escherichia coli, preventing their attachment to intestinal walls and facilitating their excretion. Additionally, MOS appears to promote the growth of beneficial gut bacteria and stimulate the immune system, leading to improved gut health and resilience against infections.

Several meta-analyses and controlled trials in livestock have shown that MOS supplementation can result in performance parameters (growth rate, feed efficiency) comparable to antibiotic growth promoters, though results can vary depending on specific conditions and animal species. However, while the evidence base is robust in animals, direct evidence for effectiveness in humans is limited. The use of MOS as antibiotic alternatives is therefore scientifically validated primarily in the context of animal nutrition, with moderate evidence supporting their efficacy in this role. Regulatory guidance and best practices continue to evolve as more data emerge.

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