Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mastic gum, a resin obtained from the Pistacia lentiscus tree, has been used traditionally in Mediterranean countries for gastrointestinal ailments. Modern research has explored its antimicrobial properties, particularly against Helicobacter pylori, a bacterium associated with peptic ulcers and gastritis. Several in vitro studies have demonstrated that mastic gum can inhibit the growth of H. pylori and some other bacteria. A few small clinical studies have suggested that mastic gum may reduce H. pylori colonization in the stomach, though results are mixed, and the quality of evidence is generally low. Despite these findings, mastic gum is not recognized as a broad-spectrum antibiotic alternative. Its antimicrobial activity appears modest and more targeted than conventional antibiotics. Systematic reviews note that while mastic gum may have some benefit for specific bacteria, especially H. pylori, there is insufficient robust clinical evidence to recommend its use as a full substitute for antibiotics in treating infections. In summary, scientific evidence exists for the antimicrobial properties of mastic gum, particularly against H. pylori, but its effectiveness as a general antibiotic alternative is limited. More high-quality, large-scale clinical trials are needed to establish its therapeutic role. Therefore, while there is a scientific basis for some uses, the overall evidence supporting mastic gum as an antibiotic alternative is limited.

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