Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Physalis angulata (commonly called cutleaf groundcherry or wild gooseberry) has a history of use in traditional medicine for various infectious diseases, and recent scientific studies have explored its potential as an alternative or adjunct to antibiotics. Laboratory research has demonstrated that extracts from different parts of the plant—particularly the leaves and fruits—contain bioactive compounds such as withanolides, physalins, and flavonoids. These constituents have shown in vitro antibacterial activity against several pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.

Despite these findings, the evidence remains preliminary. Most studies have been limited to laboratory settings, with very few animal studies and virtually no clinical trials in humans evaluating its efficacy as an antibiotic alternative. The concentrations required for activity are often higher than those typically achieved in traditional preparations, and the safety profile in humans is not well established. While some traditional uses overlap with treatment of infectious diseases, the scientific community has not yet validated Physalis angulata as a reliable substitute for conventional antibiotics. Therefore, while there is some scientific basis for its antibacterial properties, the evidence supporting its use as an antibiotic alternative is limited and not robust enough for clinical recommendations.

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