Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Saccharomyces, particularly the species Saccharomyces boulardii, has been studied as a probiotic adjunct during antibiotic therapy rather than as a direct alternative to antibiotics. Its primary role is to support gut health and prevent antibiotic-associated diarrhea, including Clostridioides difficile infection, rather than to directly replace antibiotics in the treatment of bacterial infections.

Clinical trials and meta-analyses have shown that S. boulardii supplementation can reduce the incidence and severity of diarrhea associated with antibiotic use. The proposed mechanisms include restoration of normal gut flora, enhancement of the gut barrier, and modulation of immune responses. Notably, S. boulardii produces proteases that degrade bacterial toxins and has demonstrated the ability to inhibit pathogenic bacteria in the gut.

However, there is no strong evidence that Saccharomyces species can serve as a standalone alternative to antibiotics for treating active infections. The evidence supports its adjunctive use to mitigate side effects of antibiotics or prevent recurrent infections rather than as a replacement. Safety is generally good in healthy individuals, but caution is warranted in immunocompromised patients due to rare cases of fungemia.

In summary, while scientific evidence supports the use of Saccharomyces as a supportive agent during antibiotic therapy, it does not validate its use as a primary alternative to antibiotics for the treatment of infections.

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