Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sagebrush (referring broadly to species in the Artemisia genus, such as Artemisia tridentata or Artemisia annua) has a longstanding history in traditional medicine, particularly among Indigenous peoples of North America, as well as in traditional Chinese medicine. Historically, various Artemisia species have been used to treat infections, fevers, and wounds, which are conditions often treated with antibiotics in modern medicine. These uses are primarily based on the plant's perceived antimicrobial, antiparasitic, and anti-inflammatory properties. For example, Artemisia annua is the source of artemisinin, which is a well-established antimalarial compound, though not a direct antibiotic. Laboratory studies have demonstrated that extracts from sagebrush species can inhibit the growth of certain bacteria and fungi in vitro, but evidence in humans is lacking and no Artemisia species are established as broad-spectrum antibiotic alternatives in clinical practice. The use of sagebrush as an "alternative to antibiotics" is therefore rooted in traditional knowledge and historical use rather than robust scientific validation. While some antimicrobial activities have been observed in laboratory settings, clinical evidence is insufficient to recommend sagebrush as a substitute for antibiotics. Individuals should consult healthcare professionals before using sagebrush for antimicrobial purposes.

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