Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulfated polysaccharides, particularly those derived from marine algae (such as fucoidan, carrageenan, and ulvan), have attracted scientific interest as potential alternatives or adjuncts to antibiotics. These compounds have been shown in vitro and in some in vivo animal models to possess notable antimicrobial properties against bacteria, fungi, and viruses. The mechanisms proposed include disruption of microbial membranes, inhibition of microbial adhesion, and modulation of immune responses. Several studies have indicated their ability to inhibit the growth of antibiotic-resistant bacteria, suggesting possible utility in combating antimicrobial resistance.

However, the evidence supporting their use as true antibiotic alternatives in clinical settings is still limited. Most studies are preclinical, involving cell cultures or animal models, and there is a lack of robust human clinical trials directly demonstrating efficacy as antibiotic replacements or adjuncts. While their immunomodulatory and antimicrobial activities are promising, issues such as bioavailability, safety, standardization, and effective dosing remain to be resolved.

In summary, while the use of sulfated polysaccharides as alternatives to antibiotics is supported by a growing body of early scientific evidence, it is not yet validated for clinical use. More high-quality human studies are needed to fully establish their role and effectiveness compared to conventional antibiotics.

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