Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tea polyphenols, particularly those found in green tea such as epigallocatechin gallate (EGCG), have been researched for their antimicrobial properties and their potential role as adjuncts or alternatives to antibiotics. Several in vitro and in vivo studies have demonstrated that tea polyphenols possess direct antibacterial activity against a range of pathogens, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These compounds can disrupt bacterial cell membranes, inhibit enzyme function, and interfere with bacterial adherence and biofilm formation. Importantly, some studies have shown that tea polyphenols can act synergistically with conventional antibiotics, enhancing their efficacy and even reversing antibiotic resistance in certain strains. For example, EGCG has been found to restore the activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). However, despite promising laboratory findings, clinical evidence in humans is still limited, and there are challenges related to the bioavailability and pharmacokinetics of tea polyphenols. Thus, while the scientific basis for supporting or supplementing antibiotic therapy with tea polyphenols is growing, it is not yet robust enough for widespread clinical application. More rigorous clinical trials are needed to confirm efficacy and safety in humans.

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