Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitex negundo, commonly known as the Chinese chaste tree or Nirgundi, is widely used in traditional medicine systems such as Ayurveda, Unani, and folk medicine across Asia for its purported antimicrobial and anti-inflammatory properties. Historically, various parts of the plant—particularly the leaves—have been applied topically or consumed as decoctions to manage infections, wounds, and fevers, often as an alternative or adjunct to antibiotics before the discovery of modern antimicrobial agents. The traditional rationale is largely based on observed symptomatic relief and the plant’s ability to reduce inflammation and swelling associated with infections.

Modern scientific studies have identified several phytochemicals in Vitex negundo, such as flavonoids, iridoids, and terpenoids, which exhibit in vitro antibacterial and antifungal activity. However, these studies are mostly preliminary, conducted on laboratory strains, and do not directly translate to clinical efficacy in humans. There are no robust clinical trials confirming its effectiveness as a substitute for antibiotics in treating bacterial infections. Thus, while traditional use as an antimicrobial agent is well-documented, scientific validation remains limited and inconclusive at present.

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