Evidence supporting the use of: Bifobacterium (mixed)
For the health condition: Antibiotics (side effects of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Bifidobacterium (particularly in mixed probiotic formulations) is supported by scientific evidence for the prevention and management of side effects associated with antibiotic use, most notably antibiotic-associated diarrhea (AAD). Antibiotics can disrupt the normal gut microbiota, reducing populations of beneficial bacteria, including Bifidobacterium, and allowing pathogenic bacteria like Clostridioides difficile to proliferate. Several randomized controlled trials and meta-analyses have demonstrated that supplementation with probiotics containing Bifidobacterium species can significantly reduce the incidence of AAD in both adults and children. For example, a 2017 Cochrane review concluded that probiotics, including those with Bifidobacterium, are effective in preventing AAD. The proposed mechanisms include restoration of gut microbial balance, enhancement of mucosal barrier function, and modulation of immune responses. While most studies use multi-strain formulations (often combining Bifidobacterium with Lactobacillus species), the inclusion of Bifidobacterium is well-supported. However, evidence is stronger for prevention of diarrhea rather than other side effects such as yeast overgrowth or nausea. Overall, the use of Bifidobacterium (mixed) for mitigating certain side effects of antibiotics—especially diarrhea—is justified by a substantial body of scientific evidence, though the magnitude of benefit can vary depending on the probiotic strains, dose, and population studied.

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Products containing Bifobacterium (mixed)

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