Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black cumin (Nigella sativa) has a long history of use in traditional medicine systems, particularly in Middle Eastern, South Asian, and North African cultures. Traditionally, black cumin seeds and their oil have been used to support general health, including for symptoms related to stress and mood. While it is not a primary anxiolytic in traditional texts, some practitioners have recommended it for "calming the nerves" or promoting relaxation.

Scientific evidence supporting black cumin’s use specifically for anxiety is limited. There are a few small animal studies suggesting that thymoquinone, the primary active compound in black cumin, may have anxiolytic-like effects. For example, rodent studies have shown reduced anxiety-like behaviors following administration of thymoquinone, possibly due to its antioxidant, anti-inflammatory, and neuroprotective properties. However, robust human clinical trials are lacking. Most human studies on Nigella sativa focus on its anti-inflammatory, immunomodulatory, or metabolic effects rather than on anxiety or mood disorders.

In summary, black cumin’s use for anxiety is primarily justified by traditional practices, with only limited preclinical scientific evidence and a lack of clinical validation. More research, especially well-designed human trials, would be necessary to establish its efficacy and safety for anxiety support.

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