Evidence supporting the use of: Cannabidiol
For the health condition: Anxiety

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cannabidiol (CBD) is a non-psychoactive compound found in the cannabis plant that has gained attention for its potential anxiolytic (anxiety-reducing) properties. Several preclinical (animal) studies and a growing number of small human trials suggest that CBD may help reduce anxiety in certain contexts. For example, a 2011 study in the journal Neuropsychopharmacology found that CBD significantly reduced anxiety, cognitive impairment, and discomfort in subjects with social anxiety disorder during a simulated public speaking test compared to placebo. Other small-scale clinical trials and case reports have similarly indicated potential benefits for social anxiety and generalized anxiety disorder.

Mechanistically, CBD is thought to interact with the endocannabinoid system and serotonin receptors in the brain, both of which are involved in mood regulation and stress response. However, the overall clinical evidence remains limited. Most studies have small sample sizes, short durations, and varying dosages and formulations, making it difficult to draw firm conclusions about efficacy, optimal dosing, and safety over time. Major health authorities such as the FDA have not approved CBD for treating anxiety, and systematic reviews generally conclude that more robust, large-scale randomized controlled trials are needed to confirm these early findings.

In summary, while preliminary scientific evidence supports the potential of CBD for anxiety reduction, the quality and quantity of evidence are currently moderate, and further research is needed before CBD can be considered a standard treatment for anxiety disorders.

More about cannabidiol
More about Anxiety

Other ingredients used for Anxiety

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Agarwood
Agastache
Agmatine
Agrimony
Albizia
Alpha lactalbumin
alpha-pinene
alpha-terpineol
amino acids
Amor seco
anamu
Anemone
aniracetam
anise
apigenin
Ardisia
ash
ashwagandha
Asteraceae
Bacopa
Bacopin
bacoside
bacteria
baicalein
baicalin
Baikal Skullcap
balsam
basil
bayleaf
bee products
benegut perilla (proprietary)
bergamot
beta caryophyllene
betony
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium bifidum
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black seed
blackboard tree
Bombax
borneol
brahmi
Bupleurum
bupleurum falcatum
calamus
Calea zacatechichi
California poppy
Camellia sinensis
cannabidiol
cannabigerol
Cannabis sativa oil
Canscora
capillary artemisia
Capitate Valerian
cardamom
caryophyllene
catnip
catuaba
Centella asiatica
Centella triterpenes
chamomile
Chinese raisintree
Chinese salvia root
chrysanthemum
Cinnamomum
citron
Clary sage
Clerodendrum indicum
Clostridium butyricum
clove
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
cowslip
Curcuma
curcumin
Cymbopogon martini
damiana
DHA (docosahexaenoic acid)
dodeca-2E, 4E-dienoic acid isobutylamide
dragonhead
epigallocatechin gallate (EGCG)
Erythrina
essential oil blend
eugenol
fatty acids
fennel
Ficus religiosa
fragrant rosewood
fungus
ganoderma
gardenia
Gardenia jasminoides
gastrodia
gastrodin
Gelsemium
geranium
ginkgo biloba
ginseng
Ginsenosides
Glycine
gotu kola
Greek mountain tea
green tea
Griffonia simplicifolia
guayusa
heal-all
hemp
hemp oil
Herb Robert
herbal blend (proprietary)
hericium mushroom
honeybush
Honokiol
hops
hyperforin
Hypericum
Hyperoside
Ilex
Indian fagonia
Indian tinospora
indigo leaves
inositol
iridoids
isoliquiritigenin
jasmine
Jatamansi
jujube
jujubosides
kanna
kava
kavalactones
Kefir
kudzu
L-glycine
L-theanine
L-tryptophan
lactiplantibacillus plantarum
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus helveticus
Lactobacillus johnsonii
Lactobacillus paracasei
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus rhamnosus
Lactucarium
Lactucopicrin
Large-leaved linden
Lavandin
lavender
lemon balm
lemongrass
ligustilides
limonene
linalool
linden
lingzhi
lion's mane
lithium orotate
Litsea
longan
lotus
lupulinum
Lycopodium
maca
magnesium
magnolia
magnolol
Marjoram
Matcha
Melatonin
Mentha haplocalyx
Menthol oil
Mesembrine
Mimosa
Mimulus
Mint
Monkey flower
Monoterpenes
Motherwort
Mugwort
Muira puama
Mulungu
Myrcene
N-acetyl-cysteine (NAC)
Nardostachys
Nigella seed
Nutmeg
Nymphaea caerulea
Nymphaea nouchali
omega-3 fatty acids
oolong tea
oriental arborvitae
Oroxylum indicum
Osmanthus
Oxindole alkaloids
paeoniflorin
passionflower
Passionfruit
Patchouli oil
peony
Petiveria
Phellodendron
phellodendron amurense
Phenylpropanoids
phosphatidylserine
phytocannabinoids
Plectranthus amboinicus
Polygala
polygala root
poppy
prebiotic blend (proprietary)
pregnenolone
prepared aconite tuber
probiotics
Puerain
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
Rauvolfia
reishi mushroom
relora® (proprietary)
rhizome
Rhodiola
Rooibos
rosavins
rose
rose oil
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rue
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Salidroside
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Sandalwood
sceletium
Schisandrins
Schizandrol A
Scleranthus annus
Scoparia dulcis
Self-Heal
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Sete sangrias
Shankhpushpi
shen-chu
silk tree
skullcap
Sophora
soursop
Southern Tsangshu
Southernwood
spearmint leaf
Speedwell
Sphaeranthus indicus
Spikenard
squawvine
St. John's Wort
Stachytarpheta cayennensis
star of Bethlehem
Storax
Sumbul
sweet flag
Sweet Orange alcohol
Tagara
Tea
Terpenoids
Tetrahydropalmatine
thyme
Tinospora cordifolia
Traveler's Joy
Trichilia catigua
Uncaria
Valerenic acid
Valerian root
velvet bean
Verbena
Vervain
Vetiver
Viburnum
Violet
vitamin B
vitamin B12
vitamin B6
vitamin C
Vitex Agnus-Castus
Vitexin
Waterhyssop
White Tea
Withanolides
Wogonin
Wood betony
Xylaria nigripes
Yerba buena
Ylang ylang
Yohimbine
Yuzu
Zinc

Products containing cannabidiol

We currently have no products on Vitabase that contain this ingredient.