Evidence supporting the use of: Glycine
For the health condition: Anxiety

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycine, a non-essential amino acid, has some scientific evidence supporting its use for anxiety, although the evidence is limited and not yet robust. Glycine acts as an inhibitory neurotransmitter in the central nervous system, particularly in the spinal cord, brainstem, and retina, and also modulates NMDA (N-methyl-D-aspartate) receptors in the brain. Some preclinical studies suggest that glycine supplementation can have anxiolytic (anxiety-reducing) effects, potentially by enhancing inhibitory neurotransmission and reducing overexcitation in neural circuits associated with anxiety.

A few small human studies and case reports have explored glycine’s role in sleep improvement and reduction of subjective stress, which relates indirectly to anxiety. For example, a randomized controlled trial found that glycine improved subjective sleep quality and reduced fatigue in individuals with sleep complaints—a common comorbidity of anxiety disorders. However, direct evidence from large, well-designed clinical trials specifically targeting anxiety as a primary outcome is lacking.

While animal studies and mechanistic research provide a rationale for further investigation, current human data are insufficient to recommend glycine as a primary treatment for anxiety. Its use is not based on traditional medicine but rather on emerging scientific understanding of its neurophysiological roles. Further research is needed to clarify its efficacy and safety profile for this indication.

More about Glycine
More about Anxiety

Other ingredients used for Anxiety

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Agarwood
Agastache
Agmatine
Agrimony
Albizia
Alpha lactalbumin
alpha-pinene
alpha-terpineol
amino acids
Amor seco
anamu
Anemone
aniracetam
anise
apigenin
Ardisia
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ashwagandha
Asteraceae
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bacteria
baicalein
baicalin
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basil
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bee products
benegut perilla (proprietary)
bergamot
beta caryophyllene
betony
Bifidobacteria
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Bifidobacterium longum
black cumin
black seed
blackboard tree
Bombax
borneol
brahmi
Bupleurum
bupleurum falcatum
calamus
Calea zacatechichi
California poppy
Camellia sinensis
cannabidiol
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Cannabis sativa oil
Canscora
capillary artemisia
Capitate Valerian
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caryophyllene
catnip
catuaba
Centella asiatica
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chamomile
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chrysanthemum
Cinnamomum
citron
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clove
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Curcuma
curcumin
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damiana
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Products containing Glycine

We currently have no products on Vitabase that contain this ingredient.