Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine is a non-essential amino acid that serves several physiological roles, including functioning as an inhibitory neurotransmitter in the central nervous system. Its use for anxiety is primarily supported by its mechanism of enhancing glycinergic neurotransmission, which can have calming effects on the brain. Some preclinical and limited clinical studies suggest that glycine supplementation may help reduce symptoms of anxiety and improve sleep quality, both of which are closely linked. For example, small human studies have shown that glycine can improve subjective sleep quality and reduce fatigue, which may indirectly reduce anxiety. In animal models, glycine has demonstrated anxiolytic (anxiety-reducing) properties, likely through modulation of NMDA and glycine receptor activity. However, robust, large-scale clinical trials specifically evaluating glycine’s effectiveness in treating anxiety in humans are lacking. The evidence is currently considered preliminary, and while there is a plausible biological rationale and some supportive data, it does not yet meet the threshold for strong scientific validation. Thus, the use of L-glycine for anxiety is based on emerging scientific understanding rather than long-standing traditional use or high-quality clinical evidence.

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