Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion’s mane mushroom (Hericium erinaceus) has recently become popular as a natural supplement for supporting mental health, including symptoms of anxiety. Preclinical research (mainly animal studies) suggests that compounds in lion’s mane may have neuroprotective and anti-inflammatory effects. In rodent models, lion’s mane extract has been shown to reduce anxiety-like behaviors, possibly by promoting the expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), both of which support brain health and resilience to stress.

Human evidence is limited, but a handful of small, short-term studies have been conducted. One double-blind, placebo-controlled trial in menopausal women found that lion’s mane supplementation for four weeks modestly reduced measures of anxiety and irritation compared to placebo. Another small study in overweight or obese adults reported improved mood and sleep quality. However, these studies have small sample sizes, short durations, and often combine anxiety with other symptoms like depression or sleep disturbance, making it difficult to isolate the effect on anxiety alone.

In summary, while there is some early scientific support for lion’s mane in reducing anxiety, the evidence is preliminary and not robust. More rigorous, large-scale human trials are needed to confirm its effectiveness and safety for treating anxiety. Its use for this purpose is not primarily based on traditional medicine, but on emerging scientific research.

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