Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Saffron (Crocus sativus) has a long history of use in traditional herbal medicine, but in recent years, scientific studies have begun to investigate its effects on mood disorders, including anxiety. Several randomized controlled trials and meta-analyses have demonstrated that saffron supplementation may have beneficial effects on symptoms of anxiety, often comparable to standard pharmaceutical treatments or placebo. The proposed mechanisms include modulation of neurotransmitters such as serotonin, antioxidant properties, and anti-inflammatory effects. A 2016 meta-analysis (Lopresti & Drummond, 2016) found that saffron extract produced significant reductions in anxiety symptoms in adults, although the number of studies remains limited and sample sizes are generally small.

Most clinical studies investigating saffron and anxiety have used standardized extracts at doses ranging from 15-30 mg per day for 6-12 weeks. The safety profile of saffron is favorable at these doses, with few reported side effects. However, while evidence is promising, it is not yet conclusive: more large-scale, high-quality trials are needed to confirm efficacy and determine optimal dosing. In summary, saffron is supported by preliminary scientific evidence for the treatment or support of anxiety, warranting a moderate evidence score.

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