Waterhyssop (Bacopa monnieri), also known as Brahmi, has a long history in traditional Ayurvedic medicine for supporting cognitive function, memory, and mental clarity. In recent years, scientific studies have started to explore its anxiolytic (anxiety-reducing) properties. Several animal studies have shown that extracts of Bacopa monnieri can reduce anxiety-like behavior, possibly through modulation of neurotransmitter systems such as serotonin and dopamine. Some small human clinical trials have reported that standardized extracts of Bacopa may improve mood and reduce anxiety levels in healthy adults, though these effects are often secondary outcomes in studies primarily investigating cognitive enhancement.

For example, a randomized, double-blind, placebo-controlled study published in 2013 found that participants taking Bacopa extract for 12 weeks experienced reduced anxiety and lower scores on anxiety inventories compared to placebo. However, the number of high-quality human studies specifically targeting anxiety is relatively limited, and results are not always consistent. The precise mechanisms by which Bacopa monnieri may affect anxiety are not fully elucidated, but antioxidant effects, modulation of stress hormones, and neuroprotective properties are hypothesized to play a role.

In summary, while there is some scientific evidence supporting the use of waterhyssop for anxiety, the evidence base is modest and more rigorous, large-scale clinical trials are needed to confirm its effectiveness and safety for this indication.