Amino acid blends or complexes are sometimes used as adjuncts in the management of anxiety disorders, primarily based on the understanding that certain amino acids serve as precursors for neurotransmitters implicated in mood regulation. For example, L-tryptophan and its derivative 5-HTP are precursors to serotonin, while L-tyrosine is a precursor to dopamine and norepinephrine. Some clinical studies and biochemical rationale suggest that supplementation might influence neurotransmitter synthesis, potentially affecting anxiety symptoms.

However, the quality and quantity of clinical evidence remain limited. Randomized controlled trials specifically investigating broad amino acid blends for anxiety are sparse. Most available research focuses on individual amino acids (such as tryptophan or glycine) rather than blends, and results are mixed. Some small studies suggest possible anxiolytic effects, but these findings are not robust or consistently replicated. Major guidelines for anxiety disorders do not recommend amino acid blends as a primary or adjunctive treatment based on current evidence.

In summary, while there is a plausible biochemical basis and some preliminary research supporting individual amino acids’ roles in anxiety modulation, the use of amino acid blends for anxiety disorders is only weakly supported by scientific evidence at this time. More rigorous and targeted research is needed to establish efficacy and safety.