Evidence supporting the use of: Bacoside
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacoside is the primary active constituent of Bacopa monnieri, a traditional Ayurvedic herb also known as Brahmi. While Bacopa has a long history of use in traditional medicine for cognitive enhancement and stress adaptation, its specific effects on anxiety disorders have been increasingly investigated in recent years. Several preclinical studies (animal models) have demonstrated that bacosides have anxiolytic (anxiety-reducing) effects, likely mediated through modulation of neurotransmitter systems such as serotonin and GABA, and through antioxidant mechanisms that protect neural tissue from stress-induced damage.

Human evidence for Bacopa’s anxiolytic effects is limited but growing. A handful of randomized controlled trials (RCTs) have evaluated standardized Bacopa extracts and reported reductions in self-reported anxiety and improvements in mood, though most studies were conducted in healthy adults or those with mild cognitive impairment rather than individuals diagnosed with clinical anxiety disorders. Meta-analyses suggest small but statistically significant decreases in anxiety scores with Bacopa supplementation; however, methodological limitations (small sample sizes, varying dosages and extract standardizations, lack of clinical anxiety populations) prevent strong conclusions.

Overall, while there is preliminary scientific validation for bacoside-containing Bacopa extracts as supportive agents for anxiety reduction, the evidence base remains modest (rated 2/5) and further well-designed clinical trials are needed to confirm efficacy in anxiety disorders specifically.

More about bacoside
More about Anxiety Disorders

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5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
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valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
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lemon balm
Linden
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Lactobacillus
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Mimulus
Monoterpenes
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Mulungu
Mesembrine
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Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
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yohimbine

Products containing bacoside

We currently have no products on Vitabase that contain this ingredient.